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A lot of early tests were conducted on rats, mice, chickens, and other animals, revealing potential benefits across different organs [3]
Further, cancer stem cells trans-differentiation to endothelial cells and vascular smooth muscle-like cells has been observed in different types of tumors to promote tumor vascularization (Lugano et al., 2020)
In animal studies, AOD-9604 reduced body weight gain by over 50% in obese mice during a 19-day treatment period, and significantly increased fat oxidation all without affecting insulin sensitivity or glucose regulation.[1,3] A randomized controlled trial in humans found that participants taking 1 mg of AOD-9604 daily lost an average of 2.8 kg (~6 lbs) over 23 weeks, compared to 0.8 kg (~1.7 lbs) in the placebo group
Psychiatry 177 SunW.FunakoshiH.NakamuraT
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